Published on July 15, 2024

A hole in the heart, a rare stroke, and an advanced solution to prevent a recurrence 

Dr. Edris, MMG

One of every four adults is walking around with a literal hole in their heart, a defect that’s been there since birth. For most, surprisingly, it’s not a problem. For Mark Herbst, it could have been fatal. 

In Herbst’s case, the hole was the unusual pathway for a blood clot that formed in his leg, traveled to his heart, then passed through the tiny hole and on to his brain, causing a stroke.  

As the clot made its way up his body, Herbst didn’t know any of this was happening. He just knew he didn’t feel right. And he was concerned enough that his wife called 911. Within 15 minutes, he was in the Emergency department at Community Hospital of the Monterey Peninsula

Tests quickly confirmed what his doctors suspected: Herbst was having a stroke. Because he acted so fast and because Community Hospital is a certified Advanced Primary Stroke Center, Herbst was given tissue plasminogen activator (tPA), a drug that can break up a clot — if it’s used within 3 to 4 hours of the stroke’s start. The tPA worked; the clot dissolved, restoring blood flow to Herbst’s brain. He had no lasting effects from an attack that is often debilitating or deadly. 

The nurses and the doctors were just unbelievable. I have nothing but positive things to say about the experience I had in the hospital, the ER, and the ICU. And Dr. Edris is wonderful. I was in good hands.

— Mark Herbst, patient

Herbst spent six days in the Intensive Care Unit (ICU) for monitoring and medication. Six months later, he returned to the hospital’s Tyler Heart Institute for cardiologist Dr. Ahmad Edris to close the hole in his heart with an advanced, minimally invasive procedure, permanently blocking the pathway.  

Heart patient and his wife
Mark Herbst and his wife, Suzanne

“The nurses and the doctors were just unbelievable,” Herbst says. “I have nothing but positive things to say about the experience I had in the hospital, the ER, and the ICU. And Dr. Edris is wonderful. I was in good hands.” 

In the Emergency department, doctors believed early on that they knew the source of the blood clot: Herbst and his wife had a nonstop, 11-hour flight home from Spain the day before. Blood clots sometimes develop in legs during air travel because people are immobile for long periods.  

Finding the unusual path the clot traveled took a little longer and involved expertise from a multidisciplinary team, including cardiologists Drs. Edris and Steven Lome, neurologist, Dr. Lancelot Alexander, and hematologist Dr. Thomas Bradley.   

Normally, if a clot in the leg breaks loose, it travels to the right side of the heart and then into the lungs, causing a pulmonary embolism. To get to the brain, Edris explains, the clot would have to take a route that doesn’t usually exist, crossing through an opening between the right and left upper chambers of the heart. That pointed to a patent foramen ovale (PFO) in Herbst’s heart — the door between the upper chambers that never closed. 

In a fetus, that door allows oxygen-rich blood to bypass the lungs, which aren’t yet functioning. After a baby begins to breathe, blood flows to the lungs and the door usually closes — or at least it does for about three-quarters of the population. 

Though 25 percent of people have a PFO, strokes like Herbst’s are rare. They are even rarer at his age, 70. Most often, strokes are related to high blood pressure, obesity, lack of physical activity, smoking, or other risk factors

But Herbst didn’t fit the profile. He runs, plays tennis, and golfs. He eats well, doesn’t smoke or drink, and says a recent physical had found “my blood was good, my heart was good.” 

Edris says PFO-related strokes are often a “diagnosis of exclusion because we have to make sure we’re not missing anything else that could have caused the stroke. Our multidisciplinary team did an extensive work-up for the cause of the stroke, looking for diabetes, [high] cholesterol, clotting disorders, heart-rhythm disturbances. He didn’t have any of this.” 

But they did find a hole in his heart. Edris, Director of Interventional Cardiology and Structural Heart Disease, closed the hole by implanting a small, round, wire mesh device called an Amplatzer PFO Occluder. 

The procedure took place in a state-of-the-art hybrid operating room (OR) at Community Hospital, one of two opened in 2023. The hybrid ORs combine the features of a surgical suite with advanced imaging technology that is key to guiding minimally invasive procedures like the one performed by Edris, who placed the device using a catheter inserted through a small incision.  

Herbst is grateful for his care, delivered so close to his Monterey home.  

“They did it in 40 minutes,” he says. “Back in the recovery room, I had no pain, and I was able to walk.”  

And he is returning to Spain — this time with precautions to prevent blood clots, including taking blood thinners and wearing compression socks. 

“I’m very lucky,” he says. 

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How to make an appointment

You’ll need a referral from your doctor or a cardiologist to get care at Tyler Heart Institute. Talk to your primary care provider, search for a cardiologist, or contact us at (831) 625-4934.

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